Leptin is derived from the Greek word ‘leptos’ meaning thin. Leptin is one of the key hormones involved in hunger, metabolism and how fats and carbohydrates get stored and utilized. Leptin tells your hypothalamus that you have eaten enough and need to start burning fat. The hypothalamus is the control center of the brain for fullness and fat storage. The rate of production of leptin directly correlates with weight loss or weight gain. Women have significantly higher circulating leptin than men.
Leptin resistance is very similar to insulin resistance. With insulin resistance, chronic elevated levels of insulin make your muscle and fat cells more resistance to the action of insulin. Chronic elevated leptin levels decrease the hypothalamus sensitivity to leptin. If your body produces too much fat chronically by drinking soda or eating too much ice cream, the long term elevated leptin will desensitize your hypothalamus. As a result your hypothalamus will not respond to leptin signaling, and you eat too much.
Scientist Bai CY, et al. observed the effects of electroacupuncture (EA) on leptin and leptin receptor mRNA expression in the hypothalamus of rats with nonalcoholic fatty livers in 2010. Male rats were randomly divided into a control group, model group and electrical stimulation group. The model group was established by feeding the animals a high fat diet for 8 weeks. Electrical stimulation was applied to unilateral ST 40 and ST 36, once daily for 4 weeks. After the treatments, compared with the control group, serum triglyceride and total cholesterol levels increased significantly in the model group. While serum triglyceride and total cholesterol levels in electrical acupuncture group were reduced considerably. Electrical stimulation can lower serum triglyceride and total cholesterol levels in rats with fatty liver, which is closely related to its effects in up-regulating the expression of hypothalamic leptin and leptin receptor mRNA. This may explain how the increased leptin and leptin receptor level can help rats lose unhealthy fat induced artificially.
Luo HL and Li RH did human research to show how electrical acupuncture can optimize the level of leptin and help humans to lose weight. Sixty obesity patients with elevated leptin levels were randomly divided into a control, manual acupuncture and electrical acupuncture groups with 20 cases in each group. Liangqiu (ST 34), Xuehai (SP 10), Gongsun (SP 4), Neiting (ST 44), Tianshu (ST 25) and Fujie (SP 14) were punctured respectively once every other day for 27 times altogether. After the treatment, 5.0%, 85.0% and 95.0% of the control, manual and electrical acupuncture groups respectively lost weight. The therapeutic effects of both manual and electrical acupuncture groups were significantly higher than that of control group. Furthermore, serum Lepin levels in both manual and electrical groups decreased significantly and the effects on the electrical acupuncture groups were markedly better than those of manual acupuncture and control groups. No significant changes were found in Lepin level in control group. Both electrical acupuncture and manual acupuncture can effectively lower blood Lepin level in obesity patients, by resensitizing the hypothalamus, contributing to reduced food intake and increased metabolism. The effect of electrical acupuncture is significantly superior to that of manual acupuncture in the treatment of simple obesity.